{"id":4291,"date":"2017-02-28T20:07:26","date_gmt":"2017-02-28T19:07:26","guid":{"rendered":"http:\/\/serveiseducatius.xtec.cat\/tarragones\/?p=4291"},"modified":"2019-04-30T10:24:42","modified_gmt":"2019-04-30T08:24:42","slug":"mdomenech","status":"publish","type":"post","link":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/dinamitzacio\/trics\/mdomenech\/","title":{"rendered":"De la necessitat a la cura"},"content":{"rendered":"<p><strong><span style=\"color: #808080;\"><em><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-6444\" src=\"http:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/Mireia-Dom\u00e8nech-Oller.jpg\" alt=\"Mireia Dom\u00e8nech Oller\" width=\"177\" height=\"236\" \/>T\u00edtol:<\/em><\/span>\u00a0De la necessitat a la cura<\/strong><br \/>\n<strong><span style=\"color: #808080;\"><em>Autora:\u00a0<\/em><\/span>Mireia Dom\u00e8nech Oller<\/strong><br \/>\n<span style=\"color: #808080;\"><strong><em>Tutor:<\/em> <\/strong><\/span>Antonio Panadero Brunet<br \/>\n<span style=\"color: #808080;\"><em><strong>Modalitat:\u00a0<\/strong><\/em><\/span>Ci\u00e8ncies i tecnologia: Ci\u00e8ncies de la Salut<br \/>\n<strong><span style=\"color: #808080;\"><em>\u00c0rea curricular:<\/em><\/span>\u00a0<\/strong>Biologia \/ Bioqu\u00edmica<br \/>\n<strong><span style=\"color: #808080;\"><em>Centre:<\/em><\/span>\u00a0<\/strong>Ins Mart\u00ed l&#8217;Hum\u00e0<br \/>\n<span style=\"color: #808080;\"><em><strong>Localitat: <\/strong><\/em><\/span>Montblanc<\/p>\n<h6><strong>Objectius:<\/strong><\/h6>\n<p style=\"text-align: justify;\">Els diferents objectius es desglossen en tres parts: a nivell te\u00f2ric, a nivell pr\u00e0ctic i a nivell general. Te\u00f2ricament parlant, aquests rauen principalment en adquirir nocions b\u00e0siques sobre medicaments, con\u00e8ixer-ne les caracter\u00edstiques principals i la seva actuaci\u00f3 dins el cos hum\u00e0, esquematitzar i desenvolupar el proc\u00e9s de s\u00edntesi d\u2019un f\u00e0rmac, introduir-me dins el m\u00f3n de la qu\u00edmica computacional per veure les aplicacions de les quals disposa i ampliar els coneixements sobre l&#8217;\u00e0cid acetilsalic\u00edlic, conegut popularment com l&#8217;aspirina.<\/p>\n<p style=\"text-align: justify;\">A nivell pr\u00e0ctic, el principal objectiu \u00e9s reproduir els processos de s\u00edntesi d&#8217;un f\u00e0rmac adaptats a les meves limitacions i capacitats usant l&#8217;aspirina com a vehicle, ja que \u00e9s un f\u00e0rmac relativament senzill i altament conegut.Aquests processos engloben una part de qu\u00edmica computacional, a partir de la qual se n&#8217;estudiar\u00e0\u00a0la mol\u00e8cula d\u2019\u00e0cid acetilsalic\u00edlic per obtenir-la amb una acidesa menor; seguits de la s\u00edntesi al laboratori del f\u00e0rmac, a continuaci\u00f3 una observaci\u00f3 dels efectes que una ingesta constant de diferents dosis d\u2019aspirina causa a la <em>Drosophila melanogaster<\/em>, i per \u00faltim observar mitjan\u00e7ant enquestes els coneixements i experi\u00e8ncies que la poblaci\u00f3 disposa sobre l\u2019aspirina.<\/p>\n<p style=\"text-align: justify;\">I finalment, a nivell general la fita proposada \u00e9s aprendre a realitzar un treball correctament, amb la corresponent filtraci\u00f3 i selecci\u00f3 de la informaci\u00f3, una redacci\u00f3 adient i un aprenentatge sincer. Tanmateix recau en confirmar la devoci\u00f3 pr\u00f2pia pels camps tractats, ja que seran aquests objecte d&#8217;estudi a la Universitat i possibles candidats a representar el propi dia a dia d&#8217;una futura vida laboral.<\/p>\n<h6 style=\"text-align: justify;\"><strong>Hip\u00f2tesis:<\/strong><\/h6>\n<p style=\"text-align: justify;\">Si ens centrem amb la part pr\u00e0ctica, les hip\u00f2tesis formulades a l&#8217;inici de cada experiment s\u00f3n les seg\u00fcents:<\/p>\n<ul>\n<li style=\"text-align: justify;\">Amb la qu\u00edmica computacional s\u2019accelera el proc\u00e9s de s\u00edntesi de qualsevol f\u00e0rmac.<\/li>\n<li style=\"text-align: justify;\">\u00c9s possible trobar un derivat de l\u2019\u00e0cid acetilsalic\u00edlic amb menor acidesa.<\/li>\n<li style=\"text-align: justify;\">L\u2019aspirina causa efectes negatius si \u00e9s consumida de manera constant.<\/li>\n<li style=\"text-align: justify;\">La poblaci\u00f3 disposa d\u2019un baix grau de coneixement sobre l\u2019aspirina.<\/li>\n<\/ul>\n<h6><strong><strong>El proc\u00e9s:<\/strong><\/strong><\/h6>\n<p><em><strong>Part te\u00f2rica:<\/strong>\u00a0<\/em><\/p>\n<p>Recaptaci\u00f3 de tota la informaci\u00f3 possible sobre diferents tipus de medicaments i la seva actuaci\u00f3 dins el cos hum\u00e0, documentaci\u00f3 sobre el proc\u00e9s de s\u00edntesi que segueix qualsevol f\u00e0rmac i estudi a fons de l&#8217;aspirina.<\/p>\n<p><strong><em> Part pr\u00e0ctica:<\/em><\/strong><\/p>\n<ul>\n<li style=\"text-align: justify;\">Introducci\u00f3 a la qu\u00edmica computacional.<\/li>\n<li style=\"text-align: justify;\">Aprendre a dibuixar mol\u00e8cules virtualment en dues i tres dimensions.<\/li>\n<li style=\"text-align: justify;\">Llen\u00e7ar els c\u00e0lculs a supercomputadores i analitzar-ne els resultats.<\/li>\n<li style=\"text-align: justify;\">Modificaci\u00f3 dels radicals de la mol\u00e8cula de l&#8217;\u00e0cid acetilsalic\u00edlic i estudi de l&#8217;acidesa de l&#8217;hidrogen del grup \u00e0cid.<\/li>\n<li style=\"text-align: justify;\">S\u00edntesi de l&#8217;\u00e0cid acetilsalic\u00edlic al laboratori.<\/li>\n<li style=\"text-align: justify;\">Proves qualitatives de la subst\u00e0ncia sintetitzada (detecci\u00f3 de la pres\u00e8ncia de mid\u00f3 i de l&#8217;estat de purificaci\u00f3).<\/li>\n<li style=\"text-align: justify;\">Estudi de camp: com afecta un consum diari d&#8217;aspirina a diferents dosis a la <em>Drosophila melanogaster.<\/em><\/li>\n<li style=\"text-align: justify;\">Enquesta a la poblaci\u00f3: coneixements i experi\u00e8ncies personals de l&#8217;aspirina.<\/li>\n<li style=\"text-align: justify;\">An\u00e0lisi de tots els resultats obtinguts i elaboraci\u00f3 de les conclusions.<\/li>\n<\/ul>\n<figure id=\"attachment_4295\" aria-describedby=\"caption-attachment-4295\" style=\"width: 300px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/Aspirina.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4295 size-medium\" src=\"http:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/Aspirina-300x228.jpg\" alt=\"aspirina\" width=\"300\" height=\"228\" srcset=\"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/Aspirina-300x228.jpg 300w, https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/Aspirina-768x584.jpg 768w, https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/Aspirina-1024x778.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-4295\" class=\"wp-caption-text\">Mol\u00e8cula de l&#8217;\u00e0cid acetilsalic\u00edlic<\/figcaption><\/figure>\n<figure id=\"attachment_4296\" aria-describedby=\"caption-attachment-4296\" style=\"width: 300px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/IMG_8521.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4296 size-medium\" src=\"http:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/IMG_8521-300x225.jpg\" alt=\"img_8521\" width=\"300\" height=\"225\" srcset=\"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/IMG_8521-300x225.jpg 300w, https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/IMG_8521-768x576.jpg 768w, https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/IMG_8521-1024x768.jpg 1024w, https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-content\/uploads\/usu549\/2017\/02\/IMG_8521-200x150.jpg 200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-4296\" class=\"wp-caption-text\">Flascons amb diferents concentracions d&#8217;\u00e0cid acetilsalic\u00edlic<\/figcaption><\/figure>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><\/h6>\n<h6><strong>Conclusions:\u00a0<\/strong><\/h6>\n<p>Un cop finalitzat el treball, s&#8217;analitzen les hip\u00f2tesis formulades inicialment i es rectifiquen o es corroboren segons els resultats obtinguts:<\/p>\n<ul>\n<li>Amb la qu\u00edmica computacional s\u2019accelera el proc\u00e9s de s\u00edntesi, per\u00f2 cal tenir en compte que tot i que no sintetitza medicaments col\u00b7labora en con\u00e8ixer propietats i caracter\u00edstiques moleculars.-\u00c9s possible trobar un derivat de l\u2019\u00e0cid acetilsalic\u00edlic amb menor acidesa si substitu\u00efm els hidr\u00f2gens 1 o 4 per un grup hidroxil (-OH).<\/li>\n<li>L\u2019aspirina causa efectes negatius en la descend\u00e8ncia. Aquest fet es pot relacionar amb que es desaconsella en embarassades.<\/li>\n<li>La poblaci\u00f3 disposa d\u2019un baix grau de coneixement sobre l\u2019aspirina, especialment en embarassades, en infants i en el per\u00edode de lact\u00e0ncia.<\/li>\n<\/ul>\n<p><iframe loading=\"lazy\" style=\"border: 1px solid #CCC; border-width: 1px; margin-bottom: 5px; max-width: 100%;\" src=\"\/\/www.slideshare.net\/slideshow\/embed_code\/key\/zUz59Ikwbmqkui\" width=\"595\" height=\"485\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\"> <\/iframe><\/p>\n<h6><strong><strong>Bibliografia:<\/strong><\/strong><\/h6>\n<ul>\n<li>Feliciano Jes\u00fas Ramos, et al. La aspirina en pediatr\u00eda. Nuevos conocimientos sobre un f\u00e1rmaco centenario. Seminario m\u00e9dico, 1995, 47.2: 43-50.<\/li>\n<li>Jos\u00e9 Luis Medina-Franco, Fabi\u00e1n L\u00f3pez-Vallejo y Rafael Castillo; Dise\u00f1o de f\u00e1rmacos asistido por computadora; Octubre del 2006<\/li>\n<li>Pastor i J. \u00c1lvarez-Builla; T\u00e9cnicas QSAR en Dise\u00f1o de F\u00e1rmacos; Departamento de Qu\u00edmica Org\u00e1nica, Universidad de Alcal\u00e1, Madrid<\/li>\n<li>Valles-S\u00e1nchez, Alberto, &#8220;M\u00e9todos y Usos de la Qu\u00edmica Computacional; Computational Chemistry Methods and its Applications.&#8221;<\/li>\n<li>Escalona, J., R. Carrasco, and J. Padr\u00f3n. &#8220;Introducci\u00f3n al dise\u00f1o racional de f\u00e1rmacos.&#8221; La Habana-Cuba. Editorial Universitaria (2008).<\/li>\n<li>C. Escalona, R. Carrasco, J. A. Padr\u00f3n; \u201cIntroducci\u00f3n al dise\u00f1o de F\u00e1rmacos\u201d, La Habana-Cuba. Editorial Universitaria (2008).<\/li>\n<li>J. Cramer, Essentials of Computational Chemistry: Theories and Models, 2nd edn., Wiley, 2004.<\/li>\n<li>Marovac, Jacqueline. (2001). Investigaci\u00f3n y desarrollo de nuevos medicamentos: de la mol\u00e9cula al f\u00e1rmaco.<em>Revista m\u00e9dica de Chile<\/em>,\u00a0<em>129 <\/em>(1), 99-106.<\/li>\n<li>Laporte JR. El Ensayo Cl\u00ednico Controlado. En: Laporte JR. Principios b\u00e1sicos de investigaci\u00f3n cl\u00ednica. Ed. Zeneca farma<\/li>\n<li>Avances en el dise\u00f1o de f\u00e1rmacos asistido por computadora, Educaci\u00f3n Qu\u00edmica, Volume 26, Issue 3, Pages 180-186, Jos\u00e9 L. Medina-Franco, Eli Fern\u00e1ndez-de Gortari, J. Jes\u00fas Naveja<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Ins Mart\u00ed l&#8217;Hum\u00e0<\/p>\n","protected":false},"author":1,"featured_media":4298,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[391,70],"tags":[317,512],"class_list":["post-4291","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencies","category-trics","tag-biologia","tag-trics_ins-marti-lhuma"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/posts\/4291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/comments?post=4291"}],"version-history":[{"count":4,"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/posts\/4291\/revisions"}],"predecessor-version":[{"id":6837,"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/posts\/4291\/revisions\/6837"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/media\/4298"}],"wp:attachment":[{"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/media?parent=4291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/categories?post=4291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/serveiseducatius.xtec.cat\/tarragones\/wp-json\/wp\/v2\/tags?post=4291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}